Discriminative stimulus, reinforcing, physical dependence, and antinociceptive effects of oxycodone in mice, rats, and rhesus monkeys
by
Beardsley PM, Aceto MD, Cook CD,
Bowman ER, Newman JL, Harris LS.
Department of Pharmacology and Toxicology,
Virginia Commonwealth University,
Medical College of Virginia Campus,
Richmond, VA 23298, USA.
pbeardsl@hsc.vcu.edu
Exp Clin Psychopharmacol. 2004 Aug;12(3):163-72

ABSTRACT

Despite oxycodone's (4,5-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one) history of clinical use and the attention it has received as a drug of abuse, few reports have documented its pharmacology's relevance to its abuse or its mechanism of action. The purposes of the present study were to further characterize the analgesic effects of oxycodone, its mechanism of action, and its effects in terms of its relevance to its abuse liability. The results indicate that oxycodone had potent antinociceptive effects in the mouse paraphenylquinone writhing, hot-plate, and tail-flick assays, in which it appeared to be acting as a mu-opioid receptor agonist. It generalized to the heroin discriminative stimulus and served as a positive reinforcer in rats and completely suppressed withdrawal signs in morphine-dependent rhesus monkeys. These results suggest that the analgesic and abuse liability effects of oxycodone are likely mediated through mu-opioid receptors and provide the first laboratory report of its discriminative stimulus, reinforcing, and morphine cross-dependency effects.

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Kadian v MS Contin
The Oxycontin Doctor
Oxycodone: structure
Oxycodone: metabolism
Oxycodone plus sertraline
Tramadol versus oxycodone
Oxycodone controlled-release
Oxycontin: politics and science
OxyContin: prescribing indications
Oxycodone: a pharmacological and clinical review

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